lab member bolded, * shared authorship, # corresponding
Full list
Featured
doi: celrep.2020.107716
Huckins LM, Chatzinakos C*, Breen MS*, Hartmann J*, Klengel T*, da Silva Almeida AC, …, Ressler KJ, Stahl EA, Daskalakis NP# Analysis of genetically regulated gene expression identifies a prefrontal PTSD gene, SNRNP35, specific to military cohorts. Cell reports. 2020 Jun 2;31(9).
doi: ajp.20220478
Chatzinakos C, Pernia CD, Morrison FG, Iatrou A, McCullough KM, Schuler H, …, Daskalakis NP# Single-nucleus transcriptome profiling of dorsolateral prefrontal cortex: mechanistic roles for neuronal gene expression, including the 17q21. 31 locus, in PTSD stress response. American Journal of Psychiatry. 2023 Oct 1;180(10):739-54.
doi: science.adh3707
code: /DaskalakisLab/Daskalakis-Science2024
Daskalakis NP#, Iatrou A*, Chatzinakos C*, Jajoo A*, Snijders C*, …, Nemeroff CB, Kleinman JE, Ressler KJ, Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood. Science. 2024 May 24;384(6698):eadh3707.
Daskalakis NP#, Bagot RC, Parker KJ, Vinkers CH, de Kloet ER. The three-hit concept of vulnerability and resilience: towards understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology 2013 38(9), 1858-73. PMID: 23838101. doi: psyneuen.2013.06.008
Selected
Systems Biology of Stress
Daskalakis NP#, Iatrou A, Chatzinakos C, Jajoo A, Snijders C, …, Nemeroff CB, Kleinman JE, Ressler KJ, Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood. Science. 2024 May 24;384(6698):eadh3707. doi: science.adh3707
Chatzinakos C, Pernia CD, Morrison FG, Iatrou A, McCullough KM, Schuler H, …, Daskalakis NP# Single-nucleus transcriptome profiling of dorsolateral prefrontal cortex: mechanistic roles for neuronal gene expression, including the 17q21. 31 locus, in PTSD stress response. American Journal of Psychiatry. 2023 Oct 1;180(10):739-54. doi: ajp.20220478
Chatzinakos C, Lee D, Cai N, Vladimirov VI, Docherty A, Webb BT, Riley BP, Flint J, Kendler KS, Daskalakis NP, Bacanu SA. TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet. 2020 Dec;183(8):454-463. doi: ajmg.b.32823
Huckins LM, Chatzinakos C, Breen MS, Hartmann J, …, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP# (2020). Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Reports 31(9). doi: celrep.2020.107716
GWAS/EWAS of PTSD
Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JR, Daskalakis NP, Duncan LE, Polimanti R, et al. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics. 2024 Apr 18:1-7. doi: s41588-024-01707-9
Chatzinakos C#, Lee D, Cai N, Vladimirov VI, Webb BT, Riley BP, Flint J, Kendler KS, Ressler KJ, Daskalakis NP, Bacanu SA. Increasing the resolution and precision of psychiatric GWAS by re-imputing summary statistics using a large, diverse reference panel. Am J M—ed Genet B Neuropsychiatr Genet. 2021 Jan;186(1):16-27. doi: ajmg.b.32834
Smith, AK, Ratanatharathorn, A, Maihofer AX, Naviaux RK,…Daskalakis NP… et al. (2020). Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR. Nature communications, 11(1), 1-9. doi: s41467-020-19615-x
Logue MW, Miller MW, …Daskalakis NP…, et al. An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci. Clin Epigenetics. 2020 Mar 14;12(1):46. doi: s13148-020-0820-0
Blood Endocrine and Molecular Biomarkers
Lori A, Schultebraucks K, Galatzer-Levy I, Daskalakis NP, Katrinli S, Smith AK, Myers AJ, Richholt R, Huentelman M, Guffanti G, Wuchty S, Gould F, Harvey PD, Nemeroff CB, Jovanovic T, Gerasimov ES, Maples-Keller JL, Stevens JS, Michopoulos V, Rothbaum BO, Wingo AP, Ressler KJ. Neuropsychopharmacology. 2021 Sep;46(10):1811-1820. doi: s41386-021-01073-8
Yehuda R, Flory JD, Bierer LM, Henn-Haase C, Lehrner A, Desarnaud F, Makotkine I, Daskalakis NP, Marmar CR, Meaney MJ. Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder. Biol Psychiatry. 2015 Feb 15;77(4):356-64. PMID: 24661442. doi: biopsych.2014.02.006
Yehuda R, Daskalakis NP, Desarnaud F, Makotkine I, …, Buxbaum JD, Meaney MJ, Bierer LM. Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD. Frontiers in Psychiatry 2013, 4, 118. PMID: 24098286. doi: fpsyt.2013.00118
Brain programming by early life stress
Daskalakis NP#, Diamantopoulou A, Claessens SEF, Remmers E, Tjälve M, Oitzl MS, Champagne DL, de Kloet ER. Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation. Psychoneuroendocrinology 2014 39:39-57 PMID: 24275003. doi: psyneuen.2013.09.021
Daskalakis NP#, Oitzl MS, Schächinger H, Champagne DL, de Kloet ER (2012). Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity. Physiology & Behavior. 2012 106(5), 707-721. PMID: 22306534. doi: physbeh.2012.01.015
Daskalakis NP, Claessens SE, Laboyrie JJ, Enthoven L, Oitzl MS, Champagne DL, de Kloet ER. The newborn rat’s stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion. Horm Behav. 2011 Jul;60(2):165-76. PMID: 21570400. doi: hbeh.2011.04.003
Animal models of adult stress and fear
McCullough KM, Chatzinakos C, Hartmann J, Missig G, Neve RL, Fenster RJ, Carlezon WA Jr, Daskalakis NP, Ressler KJ. (2020) Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning. Nat Commun. Oct 14;11(1):5180. doi: s41467-020-18985-6
McCullough KM, Daskalakis NP, Gafford G, Morrison FG, Ressler KJ. (2018) Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction. Transl Psychiatry. 8(1):164. PMID: 30135420. doi: s41398-018-0190
Daskalakis NP#, Cohen H, Cai G, Buxbaum JD, Yehuda R. (2014) Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13529-34. PMID: 25114262. doi: pnas.1401660111
Intergenerational transmission of stress
Daskalakis NP, Xu C, Bader HN, Chatzinakos C, Weber P, Makotkine I, Lehrner A, Bierer LM, Binder EB, Yehuda R. Intergenerational trauma is associated with expression alterations in glucocorticoid- and immune-related genes. Neuropsychopharmacology. 2021 Mar;46(4):763-773. doi: s41386-020-00900-8.
Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB. Holocaust exposure induced intergenerational effects on FKBP5 methylation. Biological Psychiatry 2016 80(5):372-80. PMID: 26410355. doi: biopsych.2015.08.005
Yehuda R*, Daskalakis NP*, Lehrner A*, Desarnaud F, Bader HN, Makotkine I, Flory JD, Bierer LM, Meaney MJ. Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring. American Journal of Psychiatry 2014, 171(8), 872-80. PMID: 24832930. doi: ajp.2014.13121571
Reviews
Lugenbühl JF, Viho EM, Binder EB, Daskalakis NP. Stress molecular signaling in interaction with cognition. Biological Psychiatry. 2024 Oct 4. PMID: 39368530. doi: biopsych.2024.09.023
Daskalakis NP#, Provost AC, Hunter RG, Guffanti G. Noncoding RNAs: stress, glucocorticoids, and posttraumatic stress disorder. Biological psychiatry. 2018 May 15;83(10):849-65. PMID: 29559087
DOI: 10.1016/j.biopsych.2018.01.009
Dalvie S, Chatzinakos C, Al Zoubi O, Georgiadis F; PGC-PTSD Systems Biology workgroup, Lancashire L, Daskalakis NP#. From genetics to systems biology of stress-related mental disorders. Neurobiology of Stress. 2021 Sep 12;15:100393. PMID: 34584908. nstr.2021.100393
Daskalakis NP#, Rijal CM, King C, Huckins LM, Ressler KJ. Recent Genetics and Epigenetics Approaches to PTSD. Current Psychiatry Reports. 2018 20(5):30. PMID: 29623448. doi: s11920-018-0898-7
Daskalakis NP#, Bagot RC, Parker KJ, Vinkers CH, de Kloet ER. The three-hit concept of vulnerability and resilience: towards understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology 2013 38(9), 1858-73. PMID: 23838101. doi: psyneuen.2013.06.008
Daskalakis NP, Yehuda R, Diamond DM. Animal models in translational studies of PTSD. Psychoneuroendocrinology. 2013 Sep;38(9):1895-911. PMID: 23845512. doi: psyneuen.2013.06.006
Daskalakis NP#, Lehrner A, Yehuda R. Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment. Endocrinol Metab Clin North Am. 2013 42(3):503-13. PMID: 24011883. doi: ecl.2013.05.004
Editorials/Commentaries
Iatrou A, Daskalakis NP#. Unraveling the cell-type-specific molecular pathways of PTSD: integrating GWAS with brain genomic profiling and in vitro modeling. Neuropsychopharmacology. 2024 Jan 1;49(1):303-4. PMID: 37580460. doi: s41386-023-01698-x
Aruldass AR, Daskalakis NP#. Brain functional connectivity abnormalities in trauma-related dissociation. Nature Mental Health. 2023 Oct;1(10):704-6. doi: s44220-023-00132-x
Soliva-Estruch M, Tamashiro KL, Daskalakis NP#. Genetics and epigenetics of stress: New avenues for an old concept. Neurobiology of Stress. 2023 Mar;23. PMID: 36873728. doi: nstr.2023.100525
Chatzinakos C, Georgiadis F, Daskalakis NP#. GWAS meets transcriptomics: from genetic letters to transcriptomic words of neuropsychiatric risk. Neuropsychopharmacology. 2021 Jan;46(1):255. PMID: 32873903. doi: s41386-020-00835-0
Daskalakis NP#, Cohen H, Nievergelt CM, Baker DG, Buxbaum JD, Russo SJ, Yehuda R. New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibility. Experimental Neurology. 2016 284(Pt B),133-140. PMID: 27481726. doi: expneurol.2016.07.024
Daskalakis NP#, Yehuda R. Early maternal influences on stress circuitry: implications for resilience and susceptibility to physical and mental disorders. Frontiers in endocrinology. 2015 Jan 14;5:244.PMID: 25642210.
doi: fendo.2014.00244