The Daskalakis’ Neurogenomics and Translational Bioinformatics Laboratory (NG-TBL) conducts research focused on the connection between stress and brain functions. NG-TBL employs functional genomics to dissect functional epigenetic and cell-type-specific regulatory elements and risk loci underlying the genetics of stress-related mental disorders, such as PTSD, and then engages in translational research using cell culture and animal models to validate causal genes and variants.
In addition, NG-TBL employs “big data” and machine learning to investigate genotype-to-phenotype relationships related to complex neuropsychiatric traits to gain a deeper understanding of the individual differences in the expression of symptoms.
NG-TBL pursues research on these fronts and, ultimately, seeks to identify novel mechanisms and treatments for these devastating mental disorders.